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Pure spillover transmission between neurons

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Szapiro and Barbour describe a new mode of neuron-to-neuron communication mediated solely by spillover of neurotransmitter that diffuses out of the synaptic cleft to bind more distant receptors on postsynaptic neurons.

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Figure 1: Pure spillover transmission between climbing fibers and molecular layer interneurons in the cerebellum.

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Authors and Affiliations

  1. Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, 21205, Maryland, USA

    Hiroshi Nishiyama & David J Linden

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  1. Hiroshi Nishiyama
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  2. David J Linden
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The authors declare no competing financial interests.

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Nishiyama, H., Linden, D. Pure spillover transmission between neurons. Nat Neurosci 10, 675–677 (2007). https://doi.org/10.1038/nn0607-675

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