Skip to main content
SpringerLink
Log in

LTP: AMPA receptors trading places

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Many forms of LTP involve insertion of new postsynaptic AMPA receptors. Plant et al. now report transient insertion of Ca2+-permeable AMPA receptors after LTP induction, and find their activation is required for LTP maintenance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Changes in the subunit composition of AMPARs during LTP in CA1 pyramidal neurons.

Jessica Iannuzzi

References

  1. Malenka, R.C. & Bear, M.F. Neuron 44, 5–21 (2004).

    Article  CAS  Google Scholar 

  2. Malinow, R. & Malenka, R.C. Annu. Rev. Neurosci. 25, 103–126 (2002).

    Article  CAS  Google Scholar 

  3. Plant et al. Nat. Neurosci. 9, 602–604 (2006).

  4. Dingledine, R., Borges, K., Bowie, D. & Traynelis, S.F. Pharmacol. Rev. 51, 7–61 (1999).

    CAS  PubMed  Google Scholar 

  5. McBain, C.J. & Fisahn, A. Nat. Rev. Neurosci. 2, 11–23 (2001).

    Article  CAS  Google Scholar 

  6. Wenthold, R.J., Petralia, R.S., Blahos, J. II & Niedzielski, A.S. J. Neurosci. 16, 1982–1989 (1996).

    Article  CAS  Google Scholar 

  7. Kumar, S.S., Bacci, A., Kharazia, V. & Huguenard, J.R. J. Neurosci. 22, 3005–3015 (2002).

    Article  CAS  Google Scholar 

  8. Takahashi, T., Svoboda, K. & Malinow, R. Science 299, 1585–1588 (2003).

    Article  CAS  Google Scholar 

  9. Rumpel, S., LeDoux, J., Zador, A. & Malinow, R. Science 308, 83–88 (2005).

    Article  CAS  Google Scholar 

  10. Clem, R.L. & Barth, A. Neuron 49, 663–670 (2006).

    Article  CAS  Google Scholar 

  11. Bellone, C. & Lüscher, C. Nat. Neurosci. 9, 636–641 (2006).

    Article  CAS  Google Scholar 

  12. Ju, W. et al. Nat. Neurosci. 7, 244–253 (2004).

    Article  CAS  Google Scholar 

  13. Thiagarajan, T.C., Lindskog, M. & Tsien, R.W. Neuron 47, 725–737 (2005).

    Article  CAS  Google Scholar 

  14. Bagal, A.A., Kao, J.P., Tang, C.M. & Thompson, S.M. Proc. Natl. Acad. Sci. USA 102, 14434–14439 (2005).

    Article  CAS  Google Scholar 

  15. Frey, U. & Morris, R.G. Trends Neurosci 21, 181–188 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pharmacology, Physiology and Biotechnology, and Neuroscience, Brown University, Providence, 02912, Rhode Island, USA

    Julie A Kauer

  2. Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, 1201 Welch Rd., Room P105, Palo Alto, 94304, California, USA

    Robert C Malenka

Authors
  1. Julie A Kauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert C Malenka
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kauer, J., Malenka, R. LTP: AMPA receptors trading places. Nat Neurosci 9, 593–594 (2006). https://doi.org/10.1038/nn0506-593

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0506-593

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation