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NMDA receptor activity regulates transcription of antioxidant pathways

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How neurons might protect themselves from free radical damage has been a mystery. A new study suggests that synaptic NMDA receptor activity affords neuroprotection by regulating oxidation-reduction (redox) pathways via transcription.

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Figure 1: Synaptic NMDAR control of Trx and Prx activity for neuroprotection.

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Authors and Affiliations

  1. The author is at The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, with adjunct appointments at The Salk Institute for Biological Studies, The Scripps Research Institute and the University of California at San Diego, all in La Jolla, California 92037, USA. slipton@burnham.org or slipton@ucsd.edu,

    Stuart A Lipton

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  1. Stuart A Lipton
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Competing interests

Dr. Lipton is the named inventor on patents for the use of the clinically-approved and marketed drug, memantine (Namenda®), in the treatment of neurodegenerative diseases. He has no direct ownership in memantine, but under the rules of the institution where this work was performed, Harvard University, he participates in a royalty-sharing plan administered by Harvard Medical School and Children's Hospital, Bostan.

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Lipton, S. NMDA receptor activity regulates transcription of antioxidant pathways. Nat Neurosci 11, 381–382 (2008). https://doi.org/10.1038/nn0408-381

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