Antidepressants take a few weeks to act, and their effects can extend for months after the drugs are discontinued. Tsankova et al. suggest a possible molecular basis for these effects, by showing that stress and the antidepressant imipramine induce modifications of chromatin to produce more or less repressive states for gene expression.
References
Kessler, R.C. et al. J. Am. Med. Assoc. 289, 3095–3105 (2003).
Tsankova N. et al. Nat. Neurosci. 9, 519–525 (2006).
Hyman, S.E. & Nestler, E.J. Am. J. Psychiatry 153, 151–162 (1996).
Nestler, E.J. et al. Neuron 34, 13–25 (2002).
Santarelli, L. et al. Science 301, 805–809 (2003).
Berton, O. et al. Science 311, 864–868 (2006).
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Hyman, S. Even chromatin gets the blues. Nat Neurosci 9, 465–466 (2006). https://doi.org/10.1038/nn0406-465
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DOI: https://doi.org/10.1038/nn0406-465
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