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Astrocytes target presynaptic NMDA receptors to give synapses a boost

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Astrocytes modulate synaptic strength. This effect occurs, reports a new paper, because ATP-dependent vesicular release of astrocytic glutamate acts on presynaptic neuronal NMDA receptors to increase synaptic efficacy.

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Figure 1: Schematic drawing of the anatomical, neural and glial transmitter relationships causing synaptic strengthening in the dentate gyrus.

Kim Caesar

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Authors and Affiliations

  1. Rheinallt Parri is at the School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.,

    Rheinallt Parri

  2. Vincenzo Crunelli is at the School of Biosciences, Cardiff University, Cardiff CF10 3US, UK. crunelli@cardiff.ac.uk,

    Vincenzo Crunelli

Authors
  1. Rheinallt Parri
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  2. Vincenzo Crunelli
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Parri, R., Crunelli, V. Astrocytes target presynaptic NMDA receptors to give synapses a boost. Nat Neurosci 10, 271–273 (2007). https://doi.org/10.1038/nn0307-271

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