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PEDF: bridging neurovascular interactions in the stem cell niche

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Stem cells are defined by their ability to self-renew. Adult brain stem cells divide slowly, and it is unclear how their division is regulated. A new study identifies PEDF as a growth factor that promotes adult stem cell self-renewal.

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Figure 1: Schematic representation of identified functional domains of PEDF, including major phosphorylation sites and domains known to be critical for interactions with extracellular matrix.

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Authors and Affiliations

  1. Center for Cell Biology and Cancer,

    Kevin Pumiglia & Sally Temple

  2. Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, 12208, New York, USA

    Kevin Pumiglia & Sally Temple

Authors
  1. Kevin Pumiglia
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  2. Sally Temple
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Pumiglia, K., Temple, S. PEDF: bridging neurovascular interactions in the stem cell niche. Nat Neurosci 9, 299–300 (2006). https://doi.org/10.1038/nn0306-299

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