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Orphan nuclear receptors control neuronal remodeling during fly metamorphosis

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Pruning of excess branches is essential for the maturation of developing neuronal circuits. Cross-talk between TGF-β signaling and two antagonistic orphan nuclear receptors governs the pruning of larval γ neurons in the Drosophila pupa.

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Figure 1: Schematic model of axon pruning during Drosophila metamorphosis.

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  1. Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA

    Takeshi Awasaki & Tzumin Lee

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  1. Takeshi Awasaki
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  2. Tzumin Lee
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Correspondence to Takeshi Awasaki.

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Awasaki, T., Lee, T. Orphan nuclear receptors control neuronal remodeling during fly metamorphosis. Nat Neurosci 14, 6–7 (2011). https://doi.org/10.1038/nn0111-6

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