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Helping EGFR inhibition to block cancer

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Effectiveness of EGFR treatment is impaired through an early adaptive response. TNF–JNK–Axl–ERK signaling contributes to this primary resistance to EGFR inhibition and might serve as novel target to improve EGFR inhibition.

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Figure 1: GBM cells escape EGFR inhibition by activation of the TNF–JNK–Axl–ERK signaling axis.

Kim Caesar/Springer Nature

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Authors and Affiliations

  1. Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany

    Rolf Warta & Christel Herold-Mende

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  1. Rolf Warta
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  2. Christel Herold-Mende
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Correspondence to Christel Herold-Mende.

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The authors declare no competing financial interests.

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Warta, R., Herold-Mende, C. Helping EGFR inhibition to block cancer. Nat Neurosci 20, 1035–1037 (2017). https://doi.org/10.1038/nn.4605

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