During synaptic activation, the function of astrocyte endfeet depends on the vascular target: at the capillary, but not at the arteriole, a newly described P2X1R–phospholipase D2 pathway modulates prostaglandin E2 release and vessel dilation.
References
Mishra, A. et al. Nat. Neurosci. 19, 1619–1627 (2016).
Mulligan, S.J. & MacVicar, B.A. Nature 431, 195–199 (2004).
Zonta, M. et al. Nat. Neurosci. 6, 43–50 (2003).
Takano, T. et al. Nat. Neurosci. 9, 260–267 (2006).
Bonder, D.E. & McCarthy, K.D. J. Neurosci. 34, 13139–13150 (2014).
Nizar, K. et al. J. Neurosci. 33, 8411–8422 (2013).
Sun, W. et al. Science 339, 197–200 (2013).
Srinivasan, R. et al. Nat. Neurosci. 18, 708–717 (2015).
Otsu, Y. et al. Nat. Neurosci. 18, 210–218 (2015).
Hall, C.N. et al. Nature 508, 55–60 (2014).
Biesecker, K.R. et al. J. Neurosci. 36, 9435–9445 (2016).
Gordon, G.R., Choi, H.B., Rungta, R.L., Ellis-Davies, G.C. & MacVicar, B.A. Nature 456, 745–749 (2008).
Rosenegger, D.G., Tran, C.H., Wamsteeker Cusulin, J.I. & Gordon, G.R. J. Neurosci. 35, 13463–13474 (2015).
Jukovskaya, N., Tiret, P., Lecoq, J. & Charpak, S. J. Neurosci. 31, 1579–1582 (2011).
O'Herron, P. et al. Nature 534, 378–382 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Rungta, R., Charpak, S. Astrocyte endfeet march to the beat of different vessels. Nat Neurosci 19, 1539–1541 (2016). https://doi.org/10.1038/nn.4446
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.4446
- Springer Nature America, Inc.