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Removing synaptic brakes on learning

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Imaging experiments in awake mice reveal striking, circuit-specific synaptic structural remodeling of inhibitory axons during learning.

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Figure 1: Schematic of an excitatory layer 2/3 pyramidal neuron (black) contacted by a somatostatin interneuron (SOM-IN, red) on its apical dendrites and a parvalbumin interneuron (PV-IN, blue) on its perisomatic dendrites.

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Authors and Affiliations

  1. Medical Research Council Institute for Clinical Sciences, Faculty of Medicine, Hammersmith Hospital Campus, Imperial College London, London, UK

    Federico W Grillo, Lucien West & Vincenzo De Paola

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  1. Federico W Grillo
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  2. Lucien West
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  3. Vincenzo De Paola
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Correspondence to Vincenzo De Paola.

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The authors declare no competing financial interests.

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Grillo, F., West, L. & De Paola, V. Removing synaptic brakes on learning. Nat Neurosci 18, 1062–1064 (2015). https://doi.org/10.1038/nn.4073

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