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MIR137: big impacts from small changes

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Schizophrenia-linked single nucleotide polymorphisms in MIR137 alter expression of miR-137 in neurons. Abnormal expression of miR-137 affects vesicle release at presynaptic terminals and in turn alters hippocampal functioning.

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Figure 1: Enhanced expression of miR-137 restrains release of presynaptic vesicles.

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Authors and Affiliations

  1. Jinju Han, Anindita Sarkar and Fred H. Gage are in the Laboratory of Genetics, the Salk Institute for Biological Studies, La Jolla, California, USA.,

    Jinju Han, Anindita Sarkar & Fred H Gage

Authors
  1. Jinju Han
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  2. Anindita Sarkar
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  3. Fred H Gage
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Correspondence to Fred H Gage.

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The authors declare no competing financial interests.

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Han, J., Sarkar, A. & Gage, F. MIR137: big impacts from small changes. Nat Neurosci 18, 931–933 (2015). https://doi.org/10.1038/nn.4045

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