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Pain and the PAG: learning from painful mistakes

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Jeremy Bentham distilled animal behavior as avoiding pain and seeking pleasure. Now, using a combination of different methodological approaches, Roy et al. identify a neural mechanism relevant for learning to avoid pain.

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Figure 1: Main experimental findings and potential new directions for study.

References

  1. Roy, M. et al. Nat. Neurosci. 17, 1607–1612 (2014).

    Article  CAS  Google Scholar 

  2. DeWitt, E.E.J. Curr. Biol. 24, R321–R324 (2014).

    Article  CAS  Google Scholar 

  3. Ploghaus, A. et al. Proc. Natl. Acad. Sci. USA 97, 9281–9286 (2000).

    Article  CAS  Google Scholar 

  4. Seymour, B. et al. Nature 429, 664–667 (2004).

    Article  CAS  Google Scholar 

  5. McNally, G.P., Johansen, J.P. & Blair, H.T. Trends Neurosci. 34, 283–292 (2011).

    Article  CAS  Google Scholar 

  6. Carrive, P. & Morgan, M.M. Periaqueductal gray. in The Human Nervous System (eds. Paxinos, G. & Mai, J.) (Elsevier, 2004).

    Google Scholar 

  7. Linnman, C., Moulton, E.A., Barmettler, G., Becerra, L. & Borsook, D. Neuroimage 60, 505–522 (2012).

    Article  Google Scholar 

  8. McNally, G.P., Pigg, M. & Weidemann, G. J. Neurosci. 24, 6912–6919 (2004).

    Article  CAS  Google Scholar 

  9. Johansen, J.P., Tarpley, J.W., LeDoux, J.E. & Blair, H.T. Nat. Neurosci. 13, 979–986 (2010).

    Article  CAS  Google Scholar 

  10. Gwilym, S.E. et al. Arthritis Rheum. 61, 1226–1234 (2009).

    Article  Google Scholar 

  11. Guo, W. et al. J. Neurosci. 26, 126–137 (2006).

    Article  CAS  Google Scholar 

  12. Caplin, A. & Dean, M. Q. J. Econ. 123, 663–701 (2008).

    Article  Google Scholar 

  13. Wimmer, G.E., Daw, N.D. & Shohamy, D. Eur. J. Neurosci. 35, 1092–1104 (2012).

    Article  Google Scholar 

  14. Eippert, F. et al. Neuron 63, 533–543 (2009).

    Article  CAS  Google Scholar 

  15. Friston, K. & Penny, W. Neuroimage 56, 2089–2099 (2011).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Falk Eippert and Irene Tracey are at the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain and Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, UK.,

    Falk Eippert & Irene Tracey

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  1. Falk Eippert
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  2. Irene Tracey
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Correspondence to Irene Tracey.

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The authors declare no competing financial interests.

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Eippert, F., Tracey, I. Pain and the PAG: learning from painful mistakes. Nat Neurosci 17, 1438–1439 (2014). https://doi.org/10.1038/nn.3844

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