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CLEARance wars: PolyQ strikes back

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Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.

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Figure 1: The polyQ expansion mutation in the AR in SBMA interferes with the ability of AR to act as a transcriptional coactivator for TFEB in activating the CLEAR gene network.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. X. William Yang is in the Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.,

    X William Yang

  2. Ai Yamamoto is in the Departments of Neurology, Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.,

    Ai Yamamoto

Authors
  1. X William Yang
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  2. Ai Yamamoto
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Correspondence to X William Yang or Ai Yamamoto.

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The authors declare no competing financial interests.

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Yang, X., Yamamoto, A. CLEARance wars: PolyQ strikes back. Nat Neurosci 17, 1140–1142 (2014). https://doi.org/10.1038/nn.3793

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