A study shows that when mice are taught to fear an odor, both their offspring and the next generation are born fearing it. The gene for an olfactory receptor activated by the odor is specifically demethylated in the germ line and the olfactory circuits for detecting the odor are enhanced.
References
Anisman, H., Hayley, S., Kelly, O., Borowski, T. & Merali, Z. Behav. Neurosci. 115, 443–454 (2001).
Dias, B.G & Ressler, K.J. Nat. Neurosci. 17, 89–96 (2014).
Buck, L. & Axel, R. Cell 65, 175–187 (1991).
Razin, A. & Riggs, A.D. Science 210, 604–610 (1980).
Ficz, G. et al. Nature 473, 398–402 (2011).
Turner, B.M. Cell 111, 285–291 (2002).
Szyf, M. Clin. Genet. 81, 341–349 (2012).
Reik, W., Dean, W. & Walter, J. Science 293, 1089–1093 (2001).
Hajkova, P. et al. Mech. Dev. 117, 15–23 (2002).
Grossniklaus, U., Kelly, B., Ferguson-Smith, A.C., Pembrey, M. & Lindquist, S. Nat. Rev. Genet. 14, 228–235 (2013).
Rodgers, A.B., Morgan, C.P., Bronson, S.L., Revello, S. & Bale, T.L. J. Neurosci. 33, 9003–9012 (2013).
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Szyf, M. Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning. Nat Neurosci 17, 2–4 (2014). https://doi.org/10.1038/nn.3603
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DOI: https://doi.org/10.1038/nn.3603
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