Skip to main content
SpringerLink
Log in

Adolescent dopamine slows spine maturation

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

A study now identifies an unexpected function of the D2 dopamine receptor in synapse maturation during a critical period in mice. The findings may have implications for the onset of schizophrenia in humans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: D2R signaling prevents spine maturation during adolescence.

References

  1. Usiello, A. et al. Nature 408, 199–203 (2000).

    Article  CAS  Google Scholar 

  2. Xu, T.X. et al. J. Neurosci. 29, 14086–14099 (2009).

    Article  CAS  Google Scholar 

  3. Jia, J.M. et al. Nat Neurosci. 16, 1627–1636 (2013).

    Article  CAS  Google Scholar 

  4. Penzes, P. et al. Nat. Neurosci. 14, 285–293 (2011).

    Article  CAS  Google Scholar 

  5. Wang, H.D. et al. Brain Res. 1300, 58–64 (2009).

    Article  CAS  Google Scholar 

  6. Espinosa, J.S. et al. Neuron 62, 205–217 (2009).

    Article  CAS  Google Scholar 

  7. Beaulieu, J.M. et al. Cell 122, 261–273 (2005).

    Article  CAS  Google Scholar 

  8. Li, W. et al. Nat. Genet. 35, 84–89 (2003).

    Article  CAS  Google Scholar 

  9. Straub, R.E. et al. Am. J. Hum. Genet. 71, 337–348 (2002).

    Article  CAS  Google Scholar 

  10. Iizuka, Y. et al. J. Neurosci. 27, 12390–12395 (2007).

    Article  CAS  Google Scholar 

  11. Wong, D.F. et al. Science 234, 1558–1563 (1986).

    Article  CAS  Google Scholar 

  12. Monyer, H. et al. Neuron 12, 529–540 (1994).

    Article  CAS  Google Scholar 

  13. Glantz, L.A. et al. Arch. Gen. Psychiatry 57, 65–73 (2000).

    Article  CAS  Google Scholar 

  14. Olney, J.W. et al. Arch. Gen. Psychiatry 52, 998–1007 (1995).

    Article  CAS  Google Scholar 

  15. Kellendonk, C. et al. Neuron 49, 603–615 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA

    Dong-Min Yin, Wen-Cheng Xiong & Lin Mei

  2. Wen-Cheng Xiong and Lin Mei are also in the Department of Neurology, Medical College of Georgia, Georgia Regents University, and at the Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.,

    Wen-Cheng Xiong & Lin Mei

Authors
  1. Dong-Min Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wen-Cheng Xiong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lin Mei
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lin Mei.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yin, DM., Xiong, WC. & Mei, L. Adolescent dopamine slows spine maturation. Nat Neurosci 16, 1514–1516 (2013). https://doi.org/10.1038/nn.3558

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3558

  • Springer Nature America, Inc.

Search

Navigation