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Drinking through the pain

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A feature of abusive alcohol drinking has been modeled successfully in experiments with rats. The experiments show that changes in NMDA signaling in specific neural circuits accompany the transition to aversion-resistant drinking.

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Figure 1: Neural circuitry underlying aversion-insensitive alcohol consumption.

Katie Vicari

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Authors and Affiliations

  1. Department of Pharmacology, Thomas L. Kash is in the Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA,

    Thomas L Kash

  2. Veterans Affairs Medical Center and Department of Behavioral Neuroscience, John C. Crabbe is at the Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon, USA.,

    John C Crabbe

Authors
  1. Thomas L Kash
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  2. John C Crabbe
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Correspondence to Thomas L Kash or John C Crabbe.

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The authors declare no competing financial interests.

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Kash, T., Crabbe, J. Drinking through the pain. Nat Neurosci 16, 987–988 (2013). https://doi.org/10.1038/nn.3476

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