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NUB1 snubs huntingtin toxicity

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A screen now identifies a protein that regulates degradation of mutant huntingtin, which causes Huntington's disease, and manipulations show that promoting clearance of the toxic protein itself may be sufficient to halt disease.

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Figure 1: Potential mechanism of NUB1-mediated mHTT degradation and suppression of toxicity.

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Authors and Affiliations

  1. Rebecca Aron, Andrey Tsvetkov and Steven Finkbeiner are at the Gladstone Institutes and Taube-Koret Center for Neurodegenerative Disease, San Francisco, California, USA.,

    Rebecca Aron, Andrey Tsvetkov & Steven Finkbeiner

  2. Steven Finkbeiner is also in the Departments of Neurology and Physiology at the University of California, San Francisco, California, USA.,

    Steven Finkbeiner

Authors
  1. Rebecca Aron
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  2. Andrey Tsvetkov
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  3. Steven Finkbeiner
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Correspondence to Steven Finkbeiner.

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The authors declare no competing financial interests.

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Aron, R., Tsvetkov, A. & Finkbeiner, S. NUB1 snubs huntingtin toxicity. Nat Neurosci 16, 523–525 (2013). https://doi.org/10.1038/nn.3380

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