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New twist on orphan receptor GPR88 function

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Ligands for G protein–coupled receptor 88 (GPR88) have not yet been found. A new study finds that GPR88 is important in the physiology of dorsal striatal projection neurons, as well as in behaviors involving this brain region.

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Figure 1: Knockout of GPR88 leads to hyperexcitation and more regular firing patterns in striatal MSNs, as well as impairment in cued response learning.

Marina Corral

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  1. The author is at the Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.,

    David M Lovinger

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  1. David M Lovinger
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Correspondence to David M Lovinger.

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Lovinger, D. New twist on orphan receptor GPR88 function. Nat Neurosci 15, 1469–1470 (2012). https://doi.org/10.1038/nn.3244

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