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TDP-43 and FUS/TLS yield a target-rich haul in ALS

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Genome-wide approaches are used to discover the RNA-binding targets of the amyotrophic lateral sclerosis (ALS) disease protein FUS/TLS. These studies reveal some shared targets with another ALS-linked RNA-binding protein, TDP-43, suggesting common pathogenic mechanisms.

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Figure 1: Intersecting roles of TDP-43 and FUS/TLS in RNA processing.

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Authors and Affiliations

  1. Aaron D. Gitler is in the Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.,

    Aaron D Gitler

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  1. Aaron D Gitler
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Correspondence to Aaron D Gitler.

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The author declares no competing financial interests.

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Gitler, A. TDP-43 and FUS/TLS yield a target-rich haul in ALS. Nat Neurosci 15, 1467–1469 (2012). https://doi.org/10.1038/nn.3243

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