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Is the reward really worth it?

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How does the brain evaluate whether the benefits of a decision outweigh the costs? A study now reveals that neurons in the anterior cingulate cortex encode costs and benefits, and altering brain activity here biases choices away from negative outcomes. These results link anterior cingulate cortex with the regulation of emotional states.

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Figure 1: The role of the pACC during Ap-Av decision-making.

Katie Vicari

References

  1. Millan, M.J. Prog. Neurobiol. 70, 83–244 (2003).

    Article  CAS  Google Scholar 

  2. Amemori, K. & Graybiel, A.M. Nat. Neurosci. 15, 776–785 (2012).

    Article  CAS  Google Scholar 

  3. Papez, J.W. AMA Arch. Neurol. Psychiatry 38, 725–743 (1937).

    Article  Google Scholar 

  4. Paus, T. Nat. Rev. Neurosci. 2, 417–424 (2001).

    Article  CAS  Google Scholar 

  5. Kennerley, S.W. & Walton, M.E. Behav. Neurosci. 125, 297–317 (2011).

    Article  Google Scholar 

  6. Rushworth, M.F., Noonan, M.P., Boorman, E.D., Walton, M.E. & Behrens, T.E. Neuron 70, 1054–1069 (2011).

    Article  CAS  Google Scholar 

  7. Camille, N., Tsuchida, A. & Fellows, L.K. J. Neurosci. 31, 15048–15052 (2011).

    Article  CAS  Google Scholar 

  8. Mayberg, H.S. et al. Neuron 45, 651–660 (2005).

    Article  CAS  Google Scholar 

  9. Leiphart, J.W. & Valone, F.H. III. J. Neurosurg. 113, 1204–1211 (2010).

    Article  Google Scholar 

  10. Cai, X. & Padoa-Schioppa, C. J. Neurosci. 32, 3791–3808 (2012).

    Article  CAS  Google Scholar 

  11. Machens, C.K., Romo, R. & Brody, C.D. Science 307, 1121–1124 (2005).

    Article  CAS  Google Scholar 

  12. Kennerley, S.W., Behrens, T.E. & Wallis, J.D. Nat. Neurosci. 14, 1581–1589 (2011).

    Article  CAS  Google Scholar 

  13. Morrison, S.E. & Salzman, C.D. J. Neurosci. 29, 11471–11483 (2009).

    Article  CAS  Google Scholar 

  14. Kobayashi, S. et al. Neuron 51, 861–870 (2006).

    Article  CAS  Google Scholar 

  15. Walton, M.E., Kennerley, S.W., Bannerman, D.M., Phillips, P.E. & Rushworth, M.F. Neural Netw. 19, 1302–1314 (2006).

    Article  CAS  Google Scholar 

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Correspondence to Steven W Kennerley.

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Kennerley, S. Is the reward really worth it?. Nat Neurosci 15, 647–649 (2012). https://doi.org/10.1038/nn.3096

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