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NMDA receptor permeation: a light in the tunnel

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A single amino acid residue determines single-channel conductance, ion permeation and channel block in the NMDA receptor, three of the key features of this ligand-gated ion channel.

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Figure 1: A model of the GluN1-GluN2A NMDA receptor.

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Acknowledgements

The authors are supported by the US National Institutes of Health National Institute of Neurological Disorders and Stroke (NS036654 and NS065371 to S.F.T.) and by the Wellcome Trust (R41653 and R42176 to D.J.A.W.).

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Authors and Affiliations

  1. David J. A. Wyllie is in the Centre for Integrative Physiology at the University of Edinburgh, Edinburgh, UK,

    David J A Wyllie

  2. Stephen F. Traynelis is in the Department of Pharmacology at Emory University, Atlanta, Georgia, USA.,

    Stephen F Traynelis

Authors
  1. David J A Wyllie
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  2. Stephen F Traynelis
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Corresponding authors

Correspondence to David J A Wyllie or Stephen F Traynelis.

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Competing interests

S.F.T. is a member of the scientific advisory boards for Sage Therapeutics and Mnemosyne Pharmaceuticals, is a consultant for NeurOp, holds an equity position in NeurOp and is a co-inventor of Emory-owned intellectual property licensed to NeurOp.

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Wyllie, D., Traynelis, S. NMDA receptor permeation: a light in the tunnel. Nat Neurosci 15, 343–344 (2012). https://doi.org/10.1038/nn.3058

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