Skip to main content
SpringerLink
Log in

An astrocyte TRP switch for inhibition

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Are astrocytes merely housekeeping cells that maintain constant the environment of neurons or are they important for CNS information processing? Intense debate over the function of calcium signaling in astrocytes will increase with the discovery of a previously unknown mechanism by which astrocyte [Ca2+]i is regulated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Pathways regulating astrocyte [Ca2+]i.

References

  1. Hamilton, N.B. & Attwell, D. Nat. Rev. Neurosci. 11, 227–238 (2010).

    Article  CAS  Google Scholar 

  2. Shigetomi, E., Tong, X., Kwan, K.Y., Corey, D.P. & Khakh, B.S. Nat. Neurosci. 15, 70–80 (2011).

    Article  Google Scholar 

  3. Cahoy, J.D. et al. J. Neurosci. 28, 264–278 (2008).

    Article  CAS  Google Scholar 

  4. Zhang, X.F., Chen, J., Faltynek, C.R., Moreland, R.B. & Neelands, T.R. Eur. J. Neurosci. 27, 605–611 (2008).

    Article  Google Scholar 

  5. Nilius, B., Prenen, J. & Owsianik, G. J. Physiol. (Lond.) 589, 1543–1549 (2011).

    Article  CAS  Google Scholar 

  6. Takahashi, N. et al. Channels (Austin) 2, 287–298 (2008).

    Article  Google Scholar 

  7. Andersson, D.A., Gentry, C., Moss, S. & Bevan, S. J. Neurosci. 28, 2485–2494 (2008).

    Article  CAS  Google Scholar 

  8. Wang, Y.Y., Chang, R.B. & Liman, E.R. J. Neurosci. 30, 12958–12963 (2010).

    Article  CAS  Google Scholar 

  9. Gourine, A.V. et al. Science 329, 571–575 (2010).

    Article  CAS  Google Scholar 

  10. Doerner, J.F., Gisselmann, G., Hatt, H. & Wetzel, C.H. J. Biol. Chem. 282, 13180–13189 (2007).

    Article  CAS  Google Scholar 

  11. Semyanov, A., Walker, M.C. & Kullmann, D.M. Nat. Neurosci. 6, 484–490 (2003).

    Article  CAS  Google Scholar 

  12. Attwell, D. et al. Nature 468, 232–243 (2010).

    Article  CAS  Google Scholar 

  13. Di Castro, M.A. et al. Nat. Neurosci. 14, 1276–1284 (2011).

    Article  CAS  Google Scholar 

  14. Panatier, A. et al. Cell 146, 785–798 (2011).

    Article  CAS  Google Scholar 

  15. Golovina, V.A. J. Physiol. (Lond.) 564, 737–749 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laura E. Clarke and David Attwell are in the Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.,

    Laura E Clarke & David Attwell

Authors
  1. Laura E Clarke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Attwell
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David Attwell.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Clarke, L., Attwell, D. An astrocyte TRP switch for inhibition. Nat Neurosci 15, 3–4 (2012). https://doi.org/10.1038/nn.3010

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.3010

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation