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Methylation on the mind

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A study now reports the genome-wide profiling of 5-hydroxymethylcytosine, an alternate epigenetic state of DNA modification, of the mouse brain across development, aging and in a neurodevelopmental disease model.

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Figure 1: A model of genome-wide shifts in 5-hmC levels targeting different classes of genes at different stages of maturation and aging.

Katie Vicari

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Authors and Affiliations

  1. Jonathan D. Flax and Paul D. Soloway are in the Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.,

    Jonathan D Flax & Paul D Soloway

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  1. Jonathan D Flax
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  2. Paul D Soloway
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Correspondence to Paul D Soloway.

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The authors declare no competing financial interests.

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Flax, J., Soloway, P. Methylation on the mind. Nat Neurosci 14, 1494–1496 (2011). https://doi.org/10.1038/nn.2988

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