Orchestration of gene expression enables coordination between the nucleus and synapses. A report now uncovers a function for the fragile X mental retardation protein in RNA editing necessary for synaptic development.
References
Bassell, G.J. & Warren, S.T. Neuron 60, 201–214 (2008).
Bhogal, B. et al. Nat. Neurosci. 14, 1517–1524 (2011).
Jepson, J.E. & Reenan, R.A. Fly (Austin) 4, 154–158 (2010).
Jepson, J.E. et al. J. Biol. Chem. 286, 8325–8337 (2011).
Wulff, B.E., Sakurai, M. & Nishikura, K. Nat. Rev. Genet. 12, 81–85 (2011).
Hoopengardner, B., Bhalla, T., Staber, C. & Reenan, R. Science 301, 832–836 (2003).
Morabito, M.V. et al. Neurobiol. Dis. 39, 169–180 (2010).
Morabito, M.V. & Emeson, R.B. Neuropsychopharmacology 34, 246 (2009).
O'Neil, R.T. & Emeson, R.B. Neurobiol. Dis. published online, doi:10.1016/j.nbd.2011.08.026 (3 September 2011).
Kawahara, Y. et al. Science 315, 1137–1140 (2007).
Feng, Y., Gutekunst, C.A., Eberhart, D.E., Yi, H. & Warren, S.T. J. Neurosci. 17, 1539–1547 (1997).
McBride, S.M. et al. Neuron 45, 753–764 (2005).
Zhang, Y.Q. et al. Cell 107, 591–603 (2001).
Muddashetty, R. et al. Molecular Cell 42, 673–688 (2011).
Darnell, J.C. et al. Genes Dev. 19, 903–918 (2005).
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Bassell, G. Fragile balance: RNA editing tunes the synapse. Nat Neurosci 14, 1492–1494 (2011). https://doi.org/10.1038/nn.2982
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DOI: https://doi.org/10.1038/nn.2982
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