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Experience-dependent plasticity of mature adult-born neurons

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Abstract

The adult olfactory bulb and hippocampus are continuously supplied with newborn neurons that are thought to possess a capacity for plasticity only at a young neuronal age, mainly during the early stages of integration into the network. We find that the two main types of adult-born neurons in the mouse olfactory bulb undergo experience-dependent plasticity long after maturation and integration, as evidenced by stabilization of synaptic turnover rates. Thus, the potential time window for plasticity of adult-born neurons extends well into maturity.

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Figure 1: Experimental design for investigating experience-dependent plasticity of mature adult-born neurons.
Figure 2: Odor enrichment stabilizes PSD95-GFP puncta dynamics of mature abPGNs.
Figure 3: Odor enrichment stabilizes PSD95-GFP puncta dynamics of mature abGCs.

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Acknowledgements

We thank H. Spors (Max Planck Institute of Biophysics, Frankfurt, Germany) for the analysis software for the intrinsic signals. We thank Y. Adam for assistance with surgical procedures. We thank members of the Mizrahi laboratory and D. Nachmani for discussions and for commenting on the manuscript. This work was supported by European Research Council (203994) and ERA-NET (0398216) grants to A.M. Y.L. is supported by the Adams Fellowship Program of the Israel Academy of Sciences and Humanities.

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Authors and Affiliations

  1. Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel

    Yoav Livneh & Adi Mizrahi

  2. The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel

    Adi Mizrahi

Authors
  1. Yoav Livneh
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  2. Adi Mizrahi
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Contributions

Y.L. and A.M. conceived and designed the experiments. Y.L. performed the experiments and analyzed the data. Y.L. and A.M. wrote the paper.

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Correspondence to Adi Mizrahi.

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The authors declare no competing financial interests.

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Supplementary Text and Figures

Supplementary Figures 1–4 and Supplementary Methods (PDF 4358 kb)

Supplementary Movie 1

An example of two PSD95-GFP expressing abPGNs, imaged in vivo. This movie shows a z-stack acquired in vivo using two-photon microscopy. The z-stack comprises 87 images, from a depth of 117 μm to a depth of 39 μm below the surface, with z-steps of 0.9 μm between images. (AVI 3386 kb)

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Livneh, Y., Mizrahi, A. Experience-dependent plasticity of mature adult-born neurons. Nat Neurosci 15, 26–28 (2012). https://doi.org/10.1038/nn.2980

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  • DOI: https://doi.org/10.1038/nn.2980

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