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Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche

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Abstract

Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.

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Figure 1: Ivy/NGs innervate NGCs.
Figure 2: Activity patterns in 4-AP support Ivy/NG innervation.
Figure 3: Disinhibition of mature cells by Ivy/NGs predicts coordinated activity.

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Acknowledgements

We thank members of the Wadiche laboratory and A. Tzingounis for helpful comments, and A. Margolies and C. Zhao for technical assistance. This work was supported by grants from the US National Institutes of Health (5T32GM008111, 5R01NS064025 and 2P30NS047466).

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Authors and Affiliations

  1. Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Sean J Markwardt, Cristina V Dieni, Jacques I Wadiche & Linda Overstreet-Wadiche

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  1. Sean J Markwardt
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  2. Cristina V Dieni
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  3. Jacques I Wadiche
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  4. Linda Overstreet-Wadiche
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All of the authors contributed to each aspect of this work.

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Correspondence to Linda Overstreet-Wadiche.

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The authors declare no competing financial interests.

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Supplementary Figures 1–8, Supplementary Table 1 and Supplementary Methods (PDF 6892 kb)

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Markwardt, S., Dieni, C., Wadiche, J. et al. Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche. Nat Neurosci 14, 1407–1409 (2011). https://doi.org/10.1038/nn.2935

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