Abstract
The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell–specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.
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Acknowledgements
We thank L. Zhang, J. Ma and Y. Jiang for technical assistance and S. Goetsch for artwork. We also thank J. Johnson, C.-L. Zhang and J. Schneider for helpful comments on the manuscript. This work was supported in part by the Epilepsy Foundation (Z.G.), a US National Institutes of Health training grant (K.U.), the Texas Advanced Research Program (grant numbers 3594-0029-2007 and 10019-0013-2006), the Ellison Medical Foundation (grant number AG-NS-0371-06) and the Welch Foundation (grant number I-1660, J.H.).
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Z.G., K.U. and J.H. conducted the experiments, contributed to the data analyses and designed the study. J.L.A. contributed to the Neurod1 expression analysis, K.-A.N. and S.G. provided the Neurod1loxP/loxP mice, and A.J.E. and D.C.L. provided Nes-CreERT2 mice and contributed conceptually to the project. The manuscript was written by J.H. and commented on by all authors.
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Gao, Z., Ure, K., Ables, J. et al. Neurod1 is essential for the survival and maturation of adult-born neurons. Nat Neurosci 12, 1090–1092 (2009). https://doi.org/10.1038/nn.2385
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DOI: https://doi.org/10.1038/nn.2385
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