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Patches of face-selective cortex in the macaque frontal lobe

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Abstract

In primates, specialized occipital-temporal face areas support the visual analysis of faces, but it is unclear whether similarly specialized areas exist in the frontal lobe. Using functional magnetic resonance imaging in alert macaques, we identified three discrete regions of highly face-selective cortex in ventral prefrontal cortex, one of which was strongly lateralized to the right hemisphere. These prefrontal face patches may constitute dedicated modules for retrieving and responding to facial information.

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Figure 1: Face-selective patches in prefrontal cortex of four macaques.
Figure 2: Sensitivity of prefrontal and temporal face patches to facial expression.

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References

  1. Haxby, J.V., Hoffman, E.A. & Gobbini, M.I. Trends Cogn. Sci. 4, 223–233 (2000).

    Article  CAS  PubMed  Google Scholar 

  2. Ishai, A., Schmidt, C.F. & Boesiger, P. Brain Res. Bull. 67, 87–93 (2005).

    Article  PubMed  Google Scholar 

  3. Tsao, D.Y., Freiwald, W.A., Knutsen, T.A., Mandeville, J.B. & Tootell, R.B. Nat. Neurosci. 6, 989–995 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Pinsk, M.A., DeSimone, K., Moore, T., Gross, C.G. & Kastner, S. Proc. Natl. Acad. Sci. USA 102, 6996–7001 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hoffman, K.L., Gothard, K.M., Schmid, M.C. & Logothetis, N.K. Curr. Biol. 17, 766–772 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Kanwisher, N., McDermott, J. & Chun, M. J. Neurosci. 17, 4302–4311 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Tsao, D.Y., Freiwald, W.A., Tootell, R.B.H. & Livingstone, M.S. Science 311, 670–674 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Scalaidhe, S.P., Wilson, F.A. & Goldman-Rakic, P.S. Cereb. Cortex 9, 459–475 (1999).

    Article  CAS  PubMed  Google Scholar 

  9. Rolls, E.T., Critchley, H.D., Browning, A.S. & Inoue, K. Exp. Brain Res. 170, 74–87 (2006).

    Article  PubMed  Google Scholar 

  10. Kelley, W.M. et al. Neuron 20, 927–936 (1998).

    Article  CAS  PubMed  Google Scholar 

  11. Denys, K. et al. J. Cogn. Neurosci. 16, 1505–1516 (2004).

    Article  PubMed  Google Scholar 

  12. Rolls, E.T. The Brain and Emotion (Oxford University Press, Oxford, 1999).

    Google Scholar 

  13. Petrides, M., Cadoret, G. & Mackey, S. Nature 435, 1235–1238 (2005).

    Article  CAS  PubMed  Google Scholar 

  14. Nakahara, K., Hayashi, T., Konishi, S. & Miyashita, Y. Science 295, 1532–1536 (2002).

    Article  CAS  PubMed  Google Scholar 

  15. Petrides, M. & Pandya, D.N. Eur. J. Neurosci. 16, 291–310 (2002).

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We are grateful to K. Thoss and R. Hakizimana for technical support, M. Borisov for help with data analysis, H. Komatsu for providing pictures of macaque faces and to Guerbet for providing Sinerem. This work was supported by a Sofia Kovalevskaya Award from the Alexander von Humboldt Foundation, the German Science Foundation (DFG FR1437/3-1) and the German Ministry of Science (grant 01GO0506, Bremen Center for Advanced Imaging).

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Correspondence to Doris Y Tsao.

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Supplementary Figures 1–3, Supplementary Table 1, Supplementary Methods and Supplementary Note (PDF 1089 kb)

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Tsao, D., Schweers, N., Moeller, S. et al. Patches of face-selective cortex in the macaque frontal lobe. Nat Neurosci 11, 877–879 (2008). https://doi.org/10.1038/nn.2158

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