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Host response: Pregnancy impairs flu defences

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It is unclear why pregnant women are at high risk of severe influenza infection. Allogeneic pregnancy in mice is now shown to alter both innate and adaptive responses to influenza virus infection, enabling the emergence of more virulent virus variants.

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Figure 1: Increasingly varied influenza virus during pregnancy.

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Authors and Affiliations

  1. Department of Biology, and the Department of Epidemiology, Elodie Ghedin is at the Center for Genomics and Systems Biology, College of Arts and Sciences, College of Global Public Health, New York University, New York, New York 10003, USA.,

    Elodie Ghedin

  2. Department of Infectious Diseases, Stacey Schultz-Cherry is at Saint Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.,

    Stacey Schultz-Cherry

Authors
  1. Elodie Ghedin
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  2. Stacey Schultz-Cherry
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Correspondence to Elodie Ghedin.

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The authors declare no competing financial interests.

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Ghedin, E., Schultz-Cherry, S. Host response: Pregnancy impairs flu defences. Nat Microbiol 2, 17077 (2017). https://doi.org/10.1038/nmicrobiol.2017.77

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