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Antimicrobials: Expressing antibiotic gene clusters

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Bacterial specialized metabolites are bioactive molecules with antibacterial or other activities that are of tremendous clinical use. New work has revealed that transcript elongation is a distinct and widespread point of secondary metabolic gene regulation, which has implications for expanding drug discovery.

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Figure 1: Transcriptional regulation of secondary metabolite synthesis loci.

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  1. Justin R. Nodwell is in the Department of Biochemistry, University of Toronto, 661 University Avenue, Toronto, Ontario M5G 1M1, Canada.,

    Justin R. Nodwell

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  1. Justin R. Nodwell
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Correspondence to Justin R. Nodwell.

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Nodwell, J. Antimicrobials: Expressing antibiotic gene clusters. Nat Microbiol 2, 17061 (2017). https://doi.org/10.1038/nmicrobiol.2017.61

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