The sensor cyclic GMP–AMP synthase (cGAS) is well known to recognize viral DNA. In this issue of Nature Microbiology, infection by dengue virus (DENV), which has an RNA genome, is shown to induce mitochondrial DNA release into the cytosol, leading to cGAS activation. In turn, DENV targets cGAS to evade antiviral immunity.
References
Screaton, G., Mongkolsapaya, J., Yacoub, S. & Roberts, C. Nat. Rev. Immunol. 15, 745–759 (2015).
Aguirre, S. et al. Nat. Microbiol. 2, 17037 (2017).
Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Science 339, 786–791 (2013).
Chen, Q., Sun, L. & Chen, Z. J. Nat. Immunol. 17, 1142–1149 (2016).
Schoggins, J. W. et al. Nature 505, 691–695 (2014).
Gack, M. U. & Diamond, M. S. Curr. Opin. Virol. 20, 119–128 (2016).
Aguirre, S. et al. PLoS Pathog. 8, e1002934 (2012).
Yu, C. Y. et al. PLoS Pathog. 8, e1002780 (2012).
Heaton, N. S. & Randall, G. Cell Host Microbe 8, 422–432 (2010).
Ablasser, A. et al. Nature 503, 530–534 (2013).
West, A. P. et al. Nature 520, 553–557 (2015).
El-Bacha, T. et al. Biochim. Biophys. Acta 1772, 1158–1166 (2007).
Chatel-Chaix, L. et al. Cell Host Microbe 20, 342–356 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
van Gent, M., Gack, M. Viral pathogenesis: Dengue virus takes on cGAS. Nat Microbiol 2, 17050 (2017). https://doi.org/10.1038/nmicrobiol.2017.50
Published:
DOI: https://doi.org/10.1038/nmicrobiol.2017.50
- Springer Nature Limited