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Goodbye to brute force in antibiotic discovery?

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Widespread antibiotic resistance is a growing public health problem. Can we revive large-scale screening to keep the pipelines flowing or will we depend increasingly on biological and ecological insights?

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Authors and Affiliations

  1. Roberto Kolter is in the Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.,

    Roberto Kolter

  2. Gilles P. van Wezel is in the Department of Molecular Biotechnology, and the Department of Microbial Ecology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands, Netherlands Institute for Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The Netherlands.,

    Gilles P. van Wezel

Authors
  1. Roberto Kolter
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  2. Gilles P. van Wezel
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Correspondence to Roberto Kolter or Gilles P. van Wezel.

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Kolter, R., van Wezel, G. Goodbye to brute force in antibiotic discovery?. Nat Microbiol 1, 15020 (2016). https://doi.org/10.1038/nmicrobiol.2015.20

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