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Evolving a better-expressing GPCR

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Researchers describe a method for evolving G protein–coupled receptors (GPCRs) with greater stability and enhanced expression.

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References

  1. Sarkar, C.A. et al. Directed evolution of a G protein–coupled receptor for expression, stability, and binding selectivity. Proc. Natl. Acad. Sci. USA 105, 14808–14813 (2008).

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Authors
  1. Allison Doerr
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Doerr, A. Evolving a better-expressing GPCR. Nat Methods 5, 918–919 (2008). https://doi.org/10.1038/nmeth1108-918b

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  • DOI: https://doi.org/10.1038/nmeth1108-918b

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