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Teaching an old molecule new tricks

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Abstract

A rigorous 'directed evolution' strategy has enabled a research group to design an RNA molecule capable of inducibly activating gene transcription, demonstrating a technique with the potential for rapid generation of other highly specialized functional RNAs.

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Figure 1: The Liu group's engineered 'Clone 96,' pictured with the TMR small-molecule inducer.

References

  1. Buskirk, A.R. et al. Engineering a ligand-dependent RNA transcriptional activator. Chem. Biol. 11, 1157–1163 (2004).

    Article  CAS  Google Scholar 

  2. Buskirk, A.R. et al. In vivo evolution of an RNA-based transcriptional activator. Chem. Biol. 10, 533–540 (2003).

    Article  CAS  Google Scholar 

  3. Mandal, M. & Breaker, R. Gene regulation by riboswitches. Nat. Rev. Mol. Cell Biol. 5, 451–463 (2004).

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Authors
  1. Michael Eisenstein
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Eisenstein, M. Teaching an old molecule new tricks. Nat Methods 1, 6–7 (2004). https://doi.org/10.1038/nmeth1004-6

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  • DOI: https://doi.org/10.1038/nmeth1004-6

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