Skip to main content
Log in

The 'rare biosphere': a reality check

  • News & Views
  • Published:

From Nature Methods

View current issue Submit your manuscript

Methods for error correction and classification of metagenomic datasets suggest that the rare biosphere is not as large as previously assumed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Why a little noise is harmful to diversity estimates.

References

  1. Brady, A. & Salzberg, S.L. Nat. Methods 6, 673–676 (2009).

    Article  CAS  Google Scholar 

  2. Quince, C. et al. Nat. Methods 6, 639–641 (2009).

    Article  CAS  Google Scholar 

  3. Turnbaugh, P.J. et al. Nature 457, 480–484 (2009).

    Article  CAS  Google Scholar 

  4. Sogin, M.L. et al. Proc. Natl. Acad. Sci. USA 103, 12115–12120 (2006).

    Article  CAS  Google Scholar 

  5. Roesch, L.F. et al. ISME J. 1, 283–290 (2007).

    Article  CAS  Google Scholar 

  6. Fierer, N., Hamady, M., Lauber, C.L. & Knight, R. Proc. Natl. Acad. Sci. USA 105, 17994–17999 (2008).

    Article  CAS  Google Scholar 

  7. Tringe, S.G. & Hugenholtz, P. Curr. Opin. Microbiol. 11, 442–446 (2008).

    Article  CAS  Google Scholar 

  8. Huse, S.M., Huber, J.A., Morrison, H.G., Sogin, M.L. & Welch, D.M. Genome Biol. 8, R143 (2007).

  9. McHardy, A.C., Martin, H.G., Tsirigos, A., Hugenholtz, P. & Rigoutsos, I. Nat. Methods 4, 63–72 (2007).

    Article  CAS  Google Scholar 

  10. Ley, R.E. et al. Science 320, 1647–1651 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reeder, J., Knight, R. The 'rare biosphere': a reality check. Nat Methods 6, 636–637 (2009). https://doi.org/10.1038/nmeth0909-636

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth0909-636

  • Springer Nature America, Inc.

This article is cited by

Navigation