The short nature of microRNAs (miRNAs) has presented unique obstacles to experimental biologists. Two research papers in this issue of Nature Methods describe solutions to some of these problems and provide high-resolution data on the expression patterns of these tiny regulatory RNAs.
This is a preview of subscription content, log in via an institution to check access.
Katie Ris
References
Kloosterman, W.P. et al. Nat. Methods 3, 27–29 (2006).
Neely, L.A. et al. Nat. Methods 3, 41–46 (2006).
Kim, V.N. Mol. Cells 19, 1–15 (2005).
Bartel, D.P. Cell 116, 281–297 (2004).
Chalfie, M., Horvitz, H.R. & Sulston, J.E. Cell 24, 59–69 (1981).
Lee, R.C., Feinbaum, R.L. & Ambros, V. Cell 75, 843–854 (1993).
Thomson, J.M., Parker, J., Perou, C.M. & Hammond, S.M. Nat. Methods 1, 47–53 (2004).
Nelson, P.T. et al. Nat. Methods 1, 155–161 (2004).
Lagos-Quintana, M. et al. Curr. Biol. 12, 735–739 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hammond, S. microRNA detection comes of age. Nat Methods 3, 12–13 (2006). https://doi.org/10.1038/nmeth0106-12
Issue Date:
DOI: https://doi.org/10.1038/nmeth0106-12
- Springer Nature America, Inc.
This article is cited by
-
Electrochemical strategy for ultrasensitive detection of microRNA based on MNAzyme-mediated rolling circle amplification on a gold electrode
Microchimica Acta (2016)
-
MicroRNA (miRNA) in cancer
Cancer Cell International (2015)
-
Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management
Breast Cancer Research (2015)
-
MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications
Genome Medicine (2013)
-
An emerging role for microRNAs in NF1 tumorigenesis
Human Genomics (2012)