Abstract
Cells are minute—typically too small to be seen by the human eye. Even so, the cellular world encompasses a range of scales, from roughly a tenth of a nanometer (10−10 m) to a millimeter (10−3 m) or larger, spanning seven orders of magnitude or more. Because they are so far from our experience, it is difficult for us to envision such scales. To help our imagination grasp such dimensions, I propose the adoption of a 'perceptive scale' that can facilitate a more direct experience of cellular sizes. From this, as I argue below, will stem a new perception also of biological shape, cellular space and dynamic processes.
References
Ornes, S. Nature 536, 361–363 (2016).
Goodsell, D.S. The Machinery of Life 2nd edn. (Springer, New York, 2009).
Zoppè, M. 3D visualization of biological processes. Scientific Visualization Unit http://www.scivis.it/about (2005).
Berry, D. The Walter and Eliza Hall Institute of Medical Research. WEHI.TV. Walter+Eliza Hall Institute of Medical Research: Discoveries for Humanity http://www.wehi.edu.au/wehi-tv/wehitv (2017).
Iwasa, J. Visualization of molecular processes. University of Utah School of Medicine: Biochemistry http://biochem.web.utah.edu/iwasa/projects.html (2017).
Eames, C. & Eames, R. (directors). Powers of Ten. http://www.eamesoffice.com/the-work/powers-of-ten/ (IBM and Office of Charles & Ray Eames, 1977).
Klement, O., Bixby, J., Duncan, D. & Kleiner, H. Fantastic Voyage. Directed by R. Fleischer. (20th Century Fox Film, 1966).
Brown, A., Fernández, I.S., Gordiyenko, Y. & Ramakrishnan, V. Nature 534, 277–280 (2016).
Lee, J.Y. et al. Nature 533, 561–564 (2016).
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Zoppè, M. Towards a perceptive understanding of size in cellular biology. Nat Methods 14, 662–665 (2017). https://doi.org/10.1038/nmeth.4300
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DOI: https://doi.org/10.1038/nmeth.4300
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