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A ligand's-eye view of protein similarity

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Classification of proteins by ligand binding similarity offers an alternative approach to evolutionary methods for organizing and understanding biology, allowing new insights into protein function and physiological signal transduction.

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Figure 1: Representation of protein space as planes containing islands of sequence-related proteins; families showing slower ligand-induced responses are toward the front of the plane.

Marina Corral

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Authors and Affiliations

  1. Gerard J.P. van Westen and John P. Overington are in the ChEMBL Group, European Molecular Biology Laboratory–European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.,

    Gerard J P van Westen & John P Overington

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  1. Gerard J P van Westen
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  2. John P Overington
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Correspondence to John P Overington.

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van Westen, G., Overington, J. A ligand's-eye view of protein similarity. Nat Methods 10, 116–117 (2013). https://doi.org/10.1038/nmeth.2339

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