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Spinning up mass spectrometry for whole protein complexes

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Researchers adapt a popular Orbitrap-based mass spectrometer to detect and analyze large, intact protein complexes, accelerating a new frontier in structural biology.

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Figure 1: Hierarchy of mass spectrometry–based proteomics.

Debbie Maizels

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Authors and Affiliations

  1. Philip D. Compton is in the Department of Chemistry, Northwestern University, Evanston, Illinois, USA.,

    Philip D Compton

  2. Neil L. Kelleher is in the Departments of Chemistry and Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.,

    Neil L Kelleher

Authors
  1. Philip D Compton
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  2. Neil L Kelleher
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Corresponding author

Correspondence to Neil L Kelleher.

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Competing interests

N.L.K. holds a sponsored research agreement with Thermo Scientific, the company that produces the Exactive Plus. P.D.C. executes the agreement.

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Compton, P., Kelleher, N. Spinning up mass spectrometry for whole protein complexes. Nat Methods 9, 1065–1066 (2012). https://doi.org/10.1038/nmeth.2216

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