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Taming the isobaric tagging elephant in the room in quantitative proteomics

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Isobaric tagging methods allow multiplexed quantitative analysis of a wide variety of proteome samples but have been severely limited by problems of accuracy. Two groups now explore this issue and provide complementary solutions to address the problem.

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Figure 1: Strategy comparison.

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Authors and Affiliations

  1. Department of Biochemistry, Andy Christoforou and Kathryn S. Lilley are at the Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.,

    Andy Christoforou & Kathryn S Lilley

Authors
  1. Andy Christoforou
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  2. Kathryn S Lilley
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Correspondence to Andy Christoforou or Kathryn S Lilley.

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The authors declare no competing financial interests.

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Christoforou, A., Lilley, K. Taming the isobaric tagging elephant in the room in quantitative proteomics. Nat Methods 8, 911–913 (2011). https://doi.org/10.1038/nmeth.1736

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