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SignalP 4.0: discriminating signal peptides from transmembrane regions

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Figure 1: Comparison of signal peptide prediction algorithm performance shown as the Matthews correlation coefficient for eukaryotes, Gram-positive bacteria and Gram-negative bacteria.

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Authors and Affiliations

  1. Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

    Thomas Nordahl Petersen, Søren Brunak & Henrik Nielsen

  2. Novo Nordisk Foundation Center for Protein Research, Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark

    Søren Brunak

  3. Department of Biochemistry and Biophysics, Center for Biomembrane Research, Stockholm University, Stockholm, Sweden

    Gunnar von Heijne

  4. Science for Life Laboratory, Stockholm University, Solna, Sweden

    Gunnar von Heijne

Authors
  1. Thomas Nordahl Petersen
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  2. Søren Brunak
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  3. Gunnar von Heijne
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  4. Henrik Nielsen
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Corresponding author

Correspondence to Henrik Nielsen.

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Competing interests

The downloadable version of SignalP 4.0 (for local use) has been commercialized by the Technical University of Denmark. (It is provided for a fee to commercial users.) The revenue from these commercial sales is divided between the program developers (T.N.P., S.B., G.v.H. and H.N.) and the Technical University of Denmark, where T.N.P., S.B. and H.N. are employed.

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Supplementary Methods, Supplementary Results (PDF 224 kb)

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Petersen, T., Brunak, S., von Heijne, G. et al. SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods 8, 785–786 (2011). https://doi.org/10.1038/nmeth.1701

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