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Arterial calcification

Conscripted by collagen

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In atherosclerotic plaques, patterns of calcification — which have profound implications for plaque stability and vulnerability to rupture — are determined by the collagen's content and patterning throughout the plaque.

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Figure 1: Effects of fibrous-cap density and disruption on plaque stability, and patterns of calcium deposition in atherosclerotic lesions.
Figure 2: The role of the extracellular matrix in orchestrating multiple physiological processes in health and disease.

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Authors and Affiliations

  1. Jordan D. Miller is in the Departments of Surgery and of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA,

    Jordan D. Miller

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  1. Jordan D. Miller
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Correspondence to Jordan D. Miller.

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Miller, J. Conscripted by collagen. Nature Mater 15, 257–258 (2016). https://doi.org/10.1038/nmat4587

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