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Stem cell reprogramming

A 3D boost

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Biophysical factors in an optimized three-dimensional microenvironment enhance the reprogramming efficiency of human somatic cells into pluripotent stem cells when compared to traditional cell-culture substrates.

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Figure 1: 3D iPSC generation.
Figure 2: High-throughput screening approach to optimize iPSC reprogramming efficiency.

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Authors and Affiliations

  1. the Department of Medicine, Oscar J. Abilez and Joseph C. Wu are at the Stanford Cardiovascular Institute, and the Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA,

    Oscar J. Abilez & Joseph C. Wu

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  1. Oscar J. Abilez
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  2. Joseph C. Wu
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Correspondence to Oscar J. Abilez or Joseph C. Wu.

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Abilez, O., Wu, J. A 3D boost. Nature Mater 15, 259–261 (2016). https://doi.org/10.1038/nmat4583

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