Skip to main content
SpringerLink
Log in

Morphogenesis

Laying down the tracks

  • News & Views
  • Published:

From Nature Materials

View current issue Submit your manuscript

To drive the formation of tubular structures, cells remodel their extracellular microenvironment to induce coordinated migration. It is now found that a mechanical feedback loop, involving the interaction of cell traction forces with collagen fibres, facilitates the formation of long epithelial tubules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Collective cell migration and tubule formation.

References

  1. DuFort, C. C. et al. Nature Rev. Mol. Cell Biol. 12, 308–319 (2011).

    Article  CAS  Google Scholar 

  2. Paszek, M. J. et al. Cancer Cell 8, 241–254 (2005).

    Article  CAS  Google Scholar 

  3. Lu, P. et al. Cold Spring Harbor Perspect. Biol. 3, a005058 (2011).

    Article  Google Scholar 

  4. Guo, C-L. et al. Proc. Natl Acad. Sci. USA 109, 5576–5582 (2012).

    Article  CAS  Google Scholar 

  5. Metzger, R. & Krasnow, M. Science 284, 1635–1639 (1999).

    Article  CAS  Google Scholar 

  6. Yamada, K. M. & Cukierman, E. Cell 130, 601–610 (2007).

    Article  CAS  Google Scholar 

  7. Page-McCaw, A. et al. Nature Rev. Mol. Cell Biol. 8, 221–233 (2007).

    Article  CAS  Google Scholar 

  8. Ingman, W. V. et al. Dev. Dyn. 235, 3222–3229 (2006).

    Article  CAS  Google Scholar 

  9. Levental, K. R. et al. Cell 139, 891–906 (2009).

    Article  CAS  Google Scholar 

  10. Mori, H. et al. Proc. Natl Acad. Sci. USA 106, 14890–14895 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Christopher C. DuFort and Valerie M. Weaver are at the Department of Surgery, Luke Cassereau, University of California San Francisco, San Francisco, California 94143-0456, USA,

    Luke Cassereau, Christopher C. DuFort & Valerie M. Weaver

Authors
  1. Luke Cassereau
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christopher C. DuFort
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Valerie M. Weaver
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Valerie M. Weaver.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cassereau, L., DuFort, C. & Weaver, V. Laying down the tracks. Nature Mater 11, 490–492 (2012). https://doi.org/10.1038/nmat3345

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat3345

  • Springer Nature Limited

This article is cited by

Search

Navigation