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Prostaglandins and reproduction—what do knockouts really tell us?

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By knocking out the proteins involved in the biosynthesis or function of prostaglandins, their role in the onset of labor is becoming clear.

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References

  1. Lim, H. et al. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell 91, 197–208 (1997).

    Article  CAS  Google Scholar 

  2. Nguyen, M.T. et al. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature 390, 78–81 (1997).

    Article  CAS  Google Scholar 

  3. Sugimoto, Y. et al. Failure of parturition in mice lacking the prostaglandin f receptor. Science 277, 681–683 (1997).

    Article  CAS  Google Scholar 

  4. Challis, J.R.G., Dilley, S.R., Robinson, J.S. & Thorburn, G.D. Prostaglandins in the circulation of the fetal lamb. Prostaglandins 11, 1041–1052 (1976).

    Article  CAS  Google Scholar 

  5. Mitchell, M.D. Eicosanoidsin Reproduction (CRC Press, Boca Raton, 1990).

  6. Negishi M. Yukihiko S. & Ichikawa A. Molecular mechanisms of diverse actions of prostanoid receptors. Biochim. Biophys. Acta 1259, 109–120 (1995).

    Article  Google Scholar 

  7. Langenbach, R. et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacininduced gastric ulceration. Cell 83, 483–492 (1995).

    Article  CAS  Google Scholar 

  8. Morham S.G. et al. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83, 473–482 (1995).

    Article  CAS  Google Scholar 

  9. Chakraborty, I., Das S.K., Wang J. & Dey S.K. Developmental expression of the cyclo-oxyge-nase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids. J. Mol. Endocrinol. 16, 107–122 (1996).

    Article  CAS  Google Scholar 

  10. Kennedy T.G. Evidence of a role for prostaglandins in the initiation of blastocyst implantation in the rat. Biol. Reprod. 16, 286–291 (1977).

    Article  CAS  Google Scholar 

  11. Challis, J.R.C. & Lye, S.J. Parturition. In The Physiology of Reproduction (eds Knobil, E. & Neill, J. D.) 985–1031 (Raven Press, New York, 1994).

    Google Scholar 

  12. Smith, W.L., Garavito, R.M. & DeWitt, D.L. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J. Biol. Chem. 271, 33157–33160 (1996).

    Article  CAS  Google Scholar 

  13. Economopoulos, P., Sun, M., Purgina, B. & Gibb, W. Glucocorticoids stimulate prostaglandin H synthase type-2 (PGHS-2) in the fibroblast cells in human amnion cultures. Mol. Cell. Endocrinol. 117, 141–147 (1996).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada, M5S 1A8

    John R.G. Challis

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  1. John R.G. Challis
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Challis, J. Prostaglandins and reproduction—what do knockouts really tell us?. Nat Med 3, 1326–1327 (1997). https://doi.org/10.1038/nm1297-1326

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  • DOI: https://doi.org/10.1038/nm1297-1326

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