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Atherosclerosis: keep your macrophages in shape

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Lipid accumulation leads to atherosclerosis partly by eliciting lethal levels of cellular stress in macrophages. A signaling pathway that drives such lipid-induced toxicity is now identified. The findings reveal a chaperoning function that might provide the clue needed to rescue this pathogenic effect (pages 1383–1391).

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Figure 1: A lipid-sensing pathway in macrophages links aP2 to toxic lipid–induced ER stress in the development of atherosclerosis.

Marina Corral

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Authors and Affiliations

  1. Xueqing Liu and James M. Ntambi are in the Department of Biochemistry, and James M. Ntambi is also in the Department of Nutritional Sciences, University of Wisconsin–Madison, Madison, Wisconsin, USA.,

    Xueqing Liu & James M Ntambi

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  1. Xueqing Liu
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  2. James M Ntambi
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Correspondence to James M Ntambi.

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Liu, X., Ntambi, J. Atherosclerosis: keep your macrophages in shape. Nat Med 15, 1357–1358 (2009). https://doi.org/10.1038/nm1209-1357

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