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Dying T cells trigger autoimmunity in HIV

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During HIV-1 infection, there are many ways for CD4+ T cells to die. New findings suggest that an autoimmune mechanism may come into play (pages 1431–1439).

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Figure 1: Apoptotic T cells are phagocytosed by dendritic cells, which 'cross-present' antigenic fragments and prime autoreactive T cells.

Kim Caesar

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Authors and Affiliations

  1. Sarah Rowland-Jones and Tao Dong are in the Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.,

    Sarah Rowland-Jones & Tao Dong

  2. Sarah Rowland-Jones is also at the MRC Laboratories, PO Box 273, The Gambia, West Africa. sarah.rowland-jones@ndm.ox.ac.uk,

    Sarah Rowland-Jones

Authors
  1. Sarah Rowland-Jones
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  2. Tao Dong
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Rowland-Jones, S., Dong, T. Dying T cells trigger autoimmunity in HIV. Nat Med 13, 1413–1415 (2007). https://doi.org/10.1038/nm1207-1413

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