Adoptive T cell transfer studies in mice and in cancer patients have shown substantial potential, but also major barriers, for successful therapeutic outcomes. A new strategy may overcome some of these barriers. T cells can now be engineered with 'autocostimulation' properties along with chimeric receptors specific for tumor antigens (pages 1440–1449).
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Kim Caesar
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Pardoll, D. Building the bionic T cell. Nat Med 13, 1411–1413 (2007). https://doi.org/10.1038/nm1207-1411
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DOI: https://doi.org/10.1038/nm1207-1411
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