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Osteoclasts, no longer osteoblast slaves

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A protein has been identified that promotes the formation of osteoclasts, bone-degrading cells—while also inhibiting osteoblasts, bone-forming cells. The findings could lead to new avenues of drug development to strengthen bone (pages 1403–1409).

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Figure 1: Osteoclast-osteoblast interaction during bone remodeling.

Kim Caesar

Figure 2: Two multinucleated osteoclasts (stained red for tartrate-resistant phosphatase activity) with ruffled border membranes are resorbing the pale pink bone beneath and to their left.

B.F. Boyce

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine and the Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, 14642, New York, USA

    Brendan F Boyce & Lianping Xing

Authors
  1. Brendan F Boyce
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  2. Lianping Xing
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Boyce, B., Xing, L. Osteoclasts, no longer osteoblast slaves. Nat Med 12, 1356–1358 (2006). https://doi.org/10.1038/nm1206-1356

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