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Micromanaging insulin secretion

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The human genome is peppered with genes for small microRNAs, whose functions are only beginning to come to light. One such microRNA is now implicated in the secretion of insulin from pancreatic beta cells.

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Figure 1: Insulin secretion and microRNA.

Deborah Maizels

References

  1. Poy A, et al. 432, 226–230 (2004).

  2. Straub, S.G. & Sharp, G.W. Diabetes. Metab. Res. Rev. 18, 451–463 (2002).

    Article  CAS  Google Scholar 

  3. Yaney, G.C. & Corkey, B.E. Diabetologia 46, 12297–12312 (2003).

    Article  Google Scholar 

  4. Burcelin, R. et al. J. Biol. Chem. 279, 1108–1115 (2004).

    Article  CAS  Google Scholar 

  5. Kulkarni, R.N. et al. Nat Genet. 31, 111–115 (2002).

    Article  CAS  Google Scholar 

  6. Lee, R.C., Feinbaum, R.L. & Ambros, V. Cell 75, 843–854 (1993).

    Article  CAS  Google Scholar 

  7. Ambros, V. Nature 431, 350–355 (2004).

    Article  CAS  Google Scholar 

  8. Mello, C.C. & Conte, D. Jr. Nature 431, 338–342 (2004).

    Article  CAS  Google Scholar 

  9. Meister, G. & Tuschl, T. Nature 431, 343–349 (2004)

    Article  CAS  Google Scholar 

  10. Thurmond, D.C., Gonelle-Gispert, C., Furukawa, M., Halban, P.A. & Pessin, J.E. Mol. Endocrinol. 17, 732–742 (2003).

    Article  CAS  Google Scholar 

  11. Nevins, A.K. & Thurmond, D.C. Am. J. Physiol. Cell Physiol. 285, C698–C710 (2003).

    Article  CAS  Google Scholar 

  12. Sarkar, S. et al. J. Biol. Chem. 279, 20422–20434 (2004).

    Article  CAS  Google Scholar 

  13. Taoka, M. et al. J. Biol. Chem. 278, 5864–5870 (2003).

    Article  CAS  Google Scholar 

  14. Holz, G.G. Diabetes 53, 5–13 (2004).

    Article  CAS  Google Scholar 

  15. Mears, D. J. Membr. Biol. 200, 57–66 (2004).

    Article  CAS  Google Scholar 

  16. Conkright, M.D. et al. Mol. Cell 12, 412–423 (2003).

    Article  Google Scholar 

Download references

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Mello, C., Czech, M. Micromanaging insulin secretion. Nat Med 10, 1297–1298 (2004). https://doi.org/10.1038/nm1204-1297

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